Since Alzheimer's is a quanitative trait, it has both genetic and environmental components. Heritability of Alzheimer's is estimated to be about .74 according to Gatz, et. al. This article can be found at http://biomed.gerontologyjournals.org/cgi/content/abstract/52/2/M117. The other .26 is due to environmental influences.
Alzheimer's doesn't develop until after reproductive stage, therefore there is no influence of selection.
Inbreeding would dicrease genetic variation and heterozygosity, therefore increasing the occurance of this trait.
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